DIAGNOSTIC IMPORTANCE OF CYTOKINE EVALUATION IN BLOOD SERUM OF CHILDREN WITH IMPAIRED RENAL FUNCTION DUE TO ASPHYXIA AT BIRTH

The article examines the features of the balance of pro-and anti-inflammatory cytokines in full-term infants with impaired renal function due to asphyxia at birth. The study involved 252 full-term newborns with signs of kidney damage: 102 children who had severe asphyxia and 150 children with moderate asphyxia. The level of interleukin -1β, interleukin -6, tumor necrosis factor α and interleukin -10 in serum determined by on the 1?2nd, 7?8th and 25?30th days of life by ELISA. Interleukin-6 is the most informative cytokine; its level increased in the first days of life in case of impaired renal function and depended on the severity of asphyxia. Determination of interleukin-1β in serum is necessary for retrospective assess severity of the asphyxia in newborns at the end of neonatal period. Serum level of interleukin-10 is closely correlated with the levels of proinflammatory cytokines in the first days of life in children with impaired renal function due to asphyxia. Character of correlation depends on the prevalence of regulatory or suppressive processes.