DNA Polymorphism of Interleukin Il-4 of Nasal Mucosal Stem Cells in Nasal Polyps of Iraqi Patients

Nasal polyposis (NP) consists of recurrent, multiple masses originating in the upper part of the nose &extend into the nasal cavity from the middle meatus, resulting in nasal blockages and restricted airflow to the olfactory region. Being of inflammatory origin, the polyp stroma is highly oedematous with a varying density of inflstreamry cells. NP are easily accessible for immunological and histologic. l studies and an increasing number of articles have appeared in recent years concerning the condition. Interleukin (IL) -4is a cytokine that which is considered to play a pivotal role in the pathogenesis of asthma & some allergic conditions was chosen to be subjected to study in this paper. DNA was extracted from NP and used polymerase chain reaction (PCR) & compared to the DNA of intact mucosa concerning IL-4 polymorphism. The aim of this study is: to clarify the role of IL- 4 polymorphism by using PCR technology in nasal mucosal stem cells in Nasal Polyps of Iraqi patients and use it as a biomarker.