Antibiotic resistance pattern of Uropathogens in a tertiary care hospital of Central India

Background: Urinary tract infection is one of the most common bacterial infections in human being. The causative agent of UTI varies from place to place and they also vary in their resistance pattern. Objective: This study was conducted to know the most common causative agents, determine distribution and resistance pattern of bacterial strains isolated from patients with UTI from a tertiary care hospital of Central India. Materials and Method: Urinary isolates from symptomatic UTI patents were identified by conventional methods. Antimicrobial susceptibility testing was performed by Kirby Bauer's disk diffusion method. Results: Of the 1800 tested samples, 696 samples showed growth of organisms among which the most prevalent were E.coli (60%), followed by Klebsiella species (10.4%).The majority of isolates were from female patients of reproductive age group. E.coli and Klebsiella spp. showed high resistance to Ampicillin, Third generation cephalosporin (3GC) and Norfloxacin and best sensitivity for Imipenem and Nitrofurantoin. Among gram positive bacteria high resistance was observed against Penicillin and Ampicillin and all isolates were sensitive to Vancomycin. Conclusion: This study revealed that UTI is more common in females particularly in reproductive age group. E.coli was the predominant bacterial pathogen. Urinary pathogens showed resistance to commonly used antibiotics like Ampicillin, 3GC and Norfloxacin. As good sensitivity was seen for Nitrofurantoin in all organisms, it can be used for empirical treatment against UTI.