ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF ASPIRIN, CLOPIDOGREL BISULPHATE AND ROSUVASTATIN CALCIUM IN FIXED DOSE COMBINATION (CAPSULE) BY UV SPECTROSCOPY

Journal: Indian Drugs (Vol.54, No. 6)

Publication Date:

Authors : ; ;

Page : 43-47

Keywords : Aspirin; Rosuvastatin calcium; Clopidogrel bisulphate; UV spectroscopy; Validation.;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

A simple, accurate and precise UV spectroscopy method has been developed for the simultaneous estimation of aspirin, rosuvastatin calcium and clopidogrel bisulphate in fixed dose combination (capsule). The third order derivative spectra were used and 290.36 nm, 243.84 nm and 256.16 nm were selected as detection wavelengths. A linear calibration curve was obtained in the concentration range of 20-100 μg/mL for aspirin; 6-20 μg/mL for rosuvastatin calcium and 10-100 μg/mL for clopidogrel bisulphate. The developed method was validated as per the ICH guidelines Q2(R1) for linearity, range, accuracy, precision, robustness, LOD, LOQ and system suitability.

Last modified: 2017-07-20 15:59:28