SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME KETONE DERIVATIVES OF GALLIC HYDRAZIDE DERIVED SCHIFF BASES

In the present study, a new series of 3,4,5-trihydroxy-N'-(1-phenylethylidene) benzohydrazide (III) has been synthesized. Methyl 3,4,5 trihydroxy benzoate (I) was synthesized from gallic acid and methanol in presence of conc. sulphuric acid. Intermediate, 3,4,5 trihydroxy benzohydrazide (II) was synthesized by reacting methyl 3,4,5 trihydroxy benzoate and hydrazine hydrate. The final compounds (IIIa-e) were synthesized by reacting compound (II) with various substituted acetophenones in presence of ethanol. The synthesized compounds have been characterized by IR, 1HNMR and Mass spectral data. The compounds were evaluated for in vitro anti-oxidant activity by DPPH and nitric oxide method. In general all compounds were found to exhibit good anti-antioxidant activity.