SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND INDAPAMIDE BY STANDARD ADDITION UV SPECTROPHOTOMETRIC METHOD IN THEIR COMBINED DOSAGE FORMS

A simple, accurate, precise, reproducible and economical UV spectroscopic method for simultaneous estimation of olmesartan medoxomil and indapamide in marketed formulation is developed. Method employs solving of simultaneous equations based on the measurement of absorbance at two wavelengths 256 nm and 240 nm which are the λmax values of olmesartan medoxomil and Indapamide in methanol. The linearity of method was investigated in range of 5-25 μg/mL for olmesartan medoxomil and 5-25 μg/mL for indapamide, respectively. The results of analyses have been validated statistically for linearity, accuracy and precision, ruggedness, solution stability, LOD and LOQ of the proposed method. This method can be successfully employed for simultaneous estimation of all drugs in commercial products.