THE CHANGES IN THE UTERUS OF OVAREICTOMIZED MICE IN RESPONSE TO PLUMERIA ACUMINATA AIT STEM EXTRACT

Objective: The primary objective of this study is to assess the effect of methanolic stem extract of Plumeria acuminata Ait. on the uterus and estrogenic/antiestrogenic potency of the plant, which are traditionally used by the Mising tribes of Assam, India for curing different reproductive ailments. Method: Extracts of the plant was prepared and given to ovariectomized mice at two dose level (200mg/kg and 400mg/kg orally). Evaluations were made based on the uterotrophic assay by observing the amount of protein, uterine wet weight, histopathological examination and serum cholesterol label. Results: The extract was found to have significant changes in the wet uterine weight and in the other biochemical parameters. Similarly the histological examination of the uterus also reveals the similar effect of the plant extract though there was non-significant change in the body weight. Conclusion: The results suggest that the stem extract of Plumeria acuminata Ait. have significant estrogenic property suggesting for a possible contraceptive activity which is consistent with the literature report on folk medicine of the plant used by the missing tribe of this region