EVALUATION OF ANETHUM GRAVEOLENS EXTRACT ON MEMORY IMPAIRED MICE

Objective:The objective of this study was to evaluate the effect of Anethum graveolens (Dill) extract on scopolamine induced learning and memory impairment in mice. The antioxidant property of Anethum graveolens was evaluated. Material and methods: A total of 36 mice (25-30 g) were randomized into 6 equal groups. Memory enhancing activity of Anethum graveolens in amnesic mice was investigated by using Elevated plus maze and Morris water maze. AchE activity, SOD and lipid peroxidation of brain homogenate were performed in control/ scopolamine/ standard / Anethum graveolens leaves extract treated mice. Result:Administrationof Anethum graveolens leaves extract significantly treated the learning and memory impairment induced by scopolamine. The effects were evaluated with the help of Morris water maze and Elevated plus maze. The study showed the significant reduction in AchE activity, increased activity of brain antioxidant enzyme such as superoxide dismutase and also reduced the increased activity of lipid peroxidation. The effects observed were dose dependent; the high dose of Anethum graveolens extract (400 mg/kg, p.o.) was most potent to show the action against learning and memory impairment. Conclusion: Anethum graveolens leaves extract has potential effect on learning and memory impairment produced by scopolamine and may have beneficial effect in the treatment of Alzheimer's disease and amnesia. Keywords: Anethum graveolens,AchE, Piracetam, scopolamine and antioxidant.