DEATH DUE TO STEVENS JOHNSON SYNDROME; A RARE CASE REPORT

Stevens Johnson's syndrome is a life threatening drug induced hypersensitivity reaction. The drugs that cause SJS commonly are antibacterials (sulfonamides), anticonvulsants (phenytoin, phenobarbital, and carbamazepine), non-steroidal anti-inflammatory drugs (oxicam derivatives) and oxide inhibitors (allopurinol).Clinical symptoms are urticarial skin eruptions, arthralgia or arthritis, lymphadenopathy and fever.Treatment of Stevens Johnsons Syndrome includes systemic steroids, cyclosporine, intravenous immunoglobulin's and supportive therapy.A male patient of 58 years was admitted in cardiology unit with chief complaints of skin reactions (Erythema andrashes) all over the body and oral erosions. The patient was diagnosed to have drug induced stevens Johnson's syndromeandthe suspected drug was amoxicillin potassium clavulanate. By using Naranjo scale and WHO-UMC scale it was found to be a probable ADR and it was managed by drug dechallenge, dexamethasone, dew on ultra-lotion, diprovate ointment. During treatment patientdeveloped severe breathlessness and died.Hence there is a need of clinical pharmacy services to detect, manage and prevent adverse drug reactions. Key words: Stevens Johnson's syndrome, amoxicillin+potassium clavulanate, Naranjo scale, Dechallenge.