Clindamycin as trigger of uroporphyrinuria

Administration of clindamycin for the management of a staphylococcal abscess of the abdominal wall was followed by development of a non-pruriginous, macular, blistery rash involving the areas of the body exposed to sunlight. This was accompanied by significant elevation of urinary uroporphyrin possibly related to the ability of clindamycin to inhibit the enzyme CYP3A4 of the P450 system. [Int J Basic Clin Pharmacol 2014; 3(1.000): 225-226]