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Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1,3-Dipolar Cycloaddition Reactions

Journal: International Journal of Advanced engineering, Management and Science (Vol.3, No. 7)

Publication Date:

Authors : ; ; ; ;

Page : 837-841

Keywords : Click cycloaddition; CuI; 1; 4-disubstituted 1; 2; 3-triazoles; 1H NMR; 13C NMR.;

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Abstract

A facile and simple protocol for the ‘Click' cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained. Compared to the uncatalyzed cycloaddition, the yields are significantly improved in the presence of CuI as catalyst, without alteration of the selectivity. The regio- and stereochemistry of the cycloadducts has been corroborated by 1H, 13C NMR spectroscopy.

Last modified: 2017-08-13 18:54:46