SECRETION AND RECRETION OF PANCREATIC ENZYMES PART 1. NON-PARALLEL SECRETION OF PANCREATIC ENZYMES

Background. Opinions on the mechanism of non-parallel enzyme secretion from the exocrine pancreas and morphological potential for the digestive enzymes synthesis are controversial. Aim. To summarize and analyze literature data on the mechanism of non-parallel secretion of pancreatic enzymes and the potentials for their synthesis de novo by exocrine cells. Material and methods. Modern original Russian and English literature sources were analyzed. Results. The changes in the exocrine cells of the pancreas during the process of postprandial secretion of digestive enzymes, revealed by electron and florescence microscopy as well as spectrophotometry using densitometric measurements of electrophoretic gels, double isotopic labeling, correlation and regression analysis were carefully considered. The pancreas energy and plasticity potentials for the synthesis of digestive enzymes de novo were alalyzed. Conclusions. 1. Selective changes in the synthesis, transport, storage, and exocytosis or chemical modifiation of individual enzymes contribute to quantitative and qualitative changes in the composition of pancreatic juice. 2. The synthesis of pancreatic enzymes de novo alone is not able to replace entirely the necessary composition of the hydrolases secreted into the intestine under circumstances in which active secretion occurs.