THE EFFECT OF GALLIC ACID ON HISTOPATHOLOGICAL AND STEREOLOGICAL OVARIAN INDEX IN ANIMAL MODEL OF POLY CYSTIC OVARIES SYNDROME

Polycystic ovary syndrome (PCOs) is a major cause of infertility due to non-ovulation. Studies have shown effects of antioxidant gallic acid. Therefore, the aim of the present study effect of Gallic acid on histopathological and stereological ovarian index in animal model of poly cystic ovaries syndrome. In this study, 40 females Wistar rats were randomly divided into five control groups (without treatment), pco group (receiving Letrozole 1mg/kg for 28 days) and PCOS groups, (receiving 50, 100, and 150 mg/kg doses of gallic acid, respectively). The gallic acid was administered per orally for 14 days. After dissection, the rats' ovaries were removed and put in 10% formalin for fixation and slides preparation processes were carried out. Finally, the study data were entered into the SPSS statistical software (v. 22) and analyzed using the Tukey test. The present study results indicated a significant decrease in the corpus luteum diameter and number of unilamminar follicles, Antral, graffian and corpus luteum and increase number of atretic and cystic follicles in the pcos group comparison to the control group (p≤0.05) which showed improvement process in high dosage treated groups. However, no significant differences were found regarding the number of primordial follicles and oocyte diameter (p≤0.05). It seems that Gallic acid affects the returning of follicogenesis in rats with PCOS and nonovulation, in a way it causes ovulation increment. Keywords: Gallic acid, Poly cystic ovarian syndrome, Histopathology, Rat