SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF SOME NEWLY SYNTHESIZED METAL COMPLEXES OF COUMARIN SCHIFF BASES

A novel series of metal complexes of coumarin Schiff bases have been synthesized by reacting to coumarin Schiff bases with cobalt (II) nitrate and zinc chloride. The IR, 1H and NMR spectral data were obtained to characterize the structures of newly synthesized compounds. Newly synthesized compounds were evaluated for acute anti-inflammatory activity using carrageenan-induced rat paw edema and analgesic activity by acetic acid induced writhing method. In acute anti-inflammatory activity, the rat paw volume was measured before and after 0.5, 1,3 and 6 h of the carrageenan injection. Compounds IIIajwere administered at a dose of 10mg/kg body weight, 0.5h before the carrageenan injection. The results showed 36.69, 45.87 and 31.19% inhibition of edematous volume at third hour against carrageenan induced paw edema.The compounds IIIa, IIIbandIIIcwere screened for analgesic activity and measured by noting the writhing response by acetic acid in mice gave 43.01, 34.05 and 26.24% of protection against acetic acid induced writhing, respectively. These results confirm the encouraging anti-inflammatory and analgesic activity of the metal complexes of coumarins Schiff bases.