DEVELOPMENT OF NEW, RAPID AND VALIDATED UV-SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF FELBAMATE IN BULK AND TABLETS

A simple, specific and accurate UV spectrophotometric method was developed to estimate felbamate in tablets. The maximum absorbance was obtained at 257.00 nm. The method showed good correlation coefficient value (r2 = 0.9984) in the concentration range of 200 - 1800 μg/mL and demonstrated specificity, accuracy, precision and robustness. It was observed that the excipients in the tablets did not interfere with the UV absorbance of drug. Results of the analysis were validated statistically and by recovery study. The developed method was found to be simple and rapid for assay of felbamate in tablet dosage form.