A LIVER CAPSULAR NETWORK OF MONOCYTE-DERIVED MACROPHAGES RESTRICTS HEPATIC DISSEMINATION OF INTRAPERITONEAL BACTERIA BY NEUTROPHIL RECRUITMENT

Macrophages of the liver in the process of differentiation are formed from monocytes, passing through a series of successive stages of development and have pronounced phagocytic properties. As a rule, tissue macrophages are in the body in two basic states: at rest (phagocytosis of lysosomes) and in the active state (larger ones, with processes, have pronounced phagocytic properties due to secretion of collagenase and elastase). The presence of specific receptors (membrane type) allows the activated macrophage to participate in the immune response of the body through the secretion of biologically active substances (which regulate the activity of lymphocytes), the destruction of immune complexes from tissues and the bloodstream. Alien microorganisms carried by blood are effectively purified in liver sinusoids by Kupffer cells, however, it is unknown how the liver prevents the spread of peritoneal pathogens penetrating into its outer membrane.