EFFICACY OF ANTIRETROVIRAL THERAPY FOR HIV-INFECTED PATIENTS DEPENDING ON THE TROPISM OF THE VIRUS

Aim of study: to evaluate the effectiveness of antiretroviral therapy(ART) for HIV-infected patients depending on the tropism of the virus. Material and methods. The analysis of the effectiveness of ART was performed in 98 HIV-infected patients, of them there were 55 (56.1%) women, 43 (43.9%) men, the average age of patients was 36.4 +5.8 years. R5-tropic variant of HIV was in 63 (64.2%), non-R5 tropic variant - in 35 (35.8%) patients. HIV tropism was determined by using the AmpliSens HIV-Resist-Seq reagent kit (Russia). Results. Therapy were administered to 41 patients (65%) of the first group and 21 (60%) patients of the 2nd group (p> 0, 05). There was no difference in the frequency of clinical and immunological indications for ART, the effectiveness of therapy on virological and immunological criteria depending on the tropism of the virus did not differ significantly. Conclusions. The presence of non-R5 tropic HIV in the patient is an indication for the first-time use of ART, since the absence of therapy in such patients is associated with disease progression, a reduction in FPR, a higher incidence of death compared to the patients infected with the R5-tropic virus.