EVALUATION OF ANTINEPHROLITHIATIC ACTIVITY OF MALLOTUS PHILIPPINENSIS LINN. IN RATS

The present study was aimed to evaluate antinephrolithiatic activity of alcoholic extract of Mallotus philippinensis Linn. on ethylene glycol (0.75% V/V) induced nephrolithiasis in rat model. The leaves of Mallotus philippinensis Linn. were extracted and antinephrolithiatic activity was evaluated at the dose of 250 & 500 mg/kg b.w., p.o. Treatment with alcoholic leaves extract of Mallotus philippinensis decreased levels of calcium oxalate, phosphate in urine and kidney homogenate. Serum levels of creatinine, urea and uric acid were also decreased significantly in curative as well as protective group as compared to model control rats. The alcoholic extract of Mallotus philippinensis Linn. at the dose of 500 mg/kg showed no microcrystalline deposition and kidney damage which enables us to confirm the protective and curative potential of Mallotus philippinensis Linn. on ethylene glycol induced nephrolithiasis in rats. It can be concluded that alcoholic leaves extract of Mallotus philippinensis possess a significant antinephrolithiatic activity.