Toxic Epidermal Necrolysis (TEN) Induced by a Combination of Phenytoin and Oxcarbazepine

Toxic Epidermal Necrolysis (TEN) or Lyell syndrome is an acute systemic inflammation that involves skin, mucous membranes, respiratory epithelia and intestinal. It is regarded as final stage of Stevens - Johnson syndrome (SJS); both entities are part of same pathophysiological and immunological process, differing only by extent of the body surface (BS) area affected. We report an 8 years old female which present a severe phenytoin and oxcarbazepine adverse reaction coursing with all clinical stages of SJS-TEN responding favorably to treatment with intravenous immunoglobulin (IGIV), without use of steroids.