A prospective, randomised, double blind controlled comparative study of antiemetic effects of ramosetron and dexamethasone with ondansetron and dexamethasone combination for prevention of post operati
Journal: Indian Journal of Clinical Anaesthesia (Vol.4, No. 3)Publication Date: 2017-09-01
Authors : Deepa Palax Kattishettar Vijayalakshmi Beladakere Channaiah.;
Page : 304-309
Keywords : Middle ear surgery; PONV; Dexamethasone; Ondansetron; Ramosetron;
Abstract
Introduction: Post operative nausea and vomiting (PONV) is one of the most frequent complications of middle ear surgery that can result in adverse physical and psychological outcomes. Various antiemetic combinations are tried for prophylaxis in high risk patients. Commonly a combination of dexamethasone and 5HT3 antagonists are used as antiemetics for preventing nausea and vomiting. We studied the efficacy of various drug combinations using dexamethasone, ondansetron and ramosetron for prevention of PONV for 24 hours post operatively in patients undergoing middle ear surgery. Aims and Objectives: To study the PONV incidence and to evaluate the efficacy of combination of ramosetron and dexamethasone in comparison to combination of ondansetron and dexamethasone and dexamethasone alone after general anaesthesia in patients undergoing middle ear surgery. Materials and Method: Ninety adult patients of American Society of Anaesthesiologists(ASA) class I and II undergoing middle ear surgery were divided randomly into three equal groups of 30 patients each. Group DO (Dexamethasone 8 mg + Ondansetron 4 mg), Group DR (Dexamethasone 8 mg + Ramosetron 0.3 mg) and Group DS (Dexamethasone 8 mg and saline). The incidence of PONV and severity of PONV, the need for rescue antiemetic therapy were observed at 0-6, 6-12, 12-18 and 18 -24 hours postoperatively. Results: The nausea and vomiting incidence was lower in Group DR in comparision to Group DO (3.33% vs 30% p= 0.044). It was much more lower in comparision to Group DS (3.33% vs 56% p = 0.000) which was highly significant in 0-6 hours postoperatively. Rescue antiemetic therapy requirement was nil in the Group DR, 16.7% in the Group DO and 50% in Group DS. In Group DR the complete response was higher in comparision to Group DO. Conclusion: Ramosetron and dexamethasone combination is preferable to ondansetron and dexamethasone combination for prevention of nausea and vomiting in the post operative period after middle ear surgery.
Other Latest Articles
- Comparison of intrathecal levobupivacaine and levobupivacaine with fentanyl in caesarean section - a randomised trial
- Combination of buprenorphine with hyperbaric bupivacaine administered either as a mixture or sequentially for spinal anaesthesia for caesarean section
- Comparison of ultrasound-guided and electrical nerve stimulation techniques for interscalene brachial plexus block in patients undergoing clavicle surgeries: A randomized clinical study
- Recent Advances on Pediatric Ventilation
- Https://www.innovativepublication.com/admin/uploaded_files/IJMMTD_3(3)_135-136.pdf
Last modified: 2017-10-09 18:37:09