USE OF ELECTROKINETIC CHARACTERISTICS OF RED BLOOD CELLS IN CANCER DIAGNOSTICS

The purpose of research is the study of the electrophoretic mobility of red blood cells in patients with malignant and benign tumors. Were investigated in erythrocytes of 25 patients with malignant tumors of epithelial tissues (colon cancer, kidney, bladder, prostate, cervix), 14 are women, 11 men aged 48 to 76 years, and 12 patients with malignant brain tumors (glioma, glioblastoma, astrocytoma) – 6 women and 6 men in the age group of 39 to 53 years, 7 patients with benign brain tumors (meningioma, subependymoma) – 3 women and 4 men aged from 37 to 59 years, not previously exposed to cancer treatment. After surgery in cancer patients, was performed histological examination of tumor material, the results of which were mounted the stage and malignancy of the tumor. As a control used blood from 10 healthy individuals (5 men and 5 women in the age group of 35 to 65 years).The comparison group consisted of patients with non-oncological pathologies, matched by sex and age: cardiovascular (acute myocardial infarction, arterial hypertension, angina pectoris, myocarditis, heart failure), broncho-pulmonary (chronic obstructive pulmonary disease, acute bronchitis, acute community-acquired pneumonia), gynecological (threat of miscarriage, chronic endometritis exacerbation, dysfuntional uterine bleeding), gastroenterological diseases (peptic ulcer, cholecystitis, acute gastritis, acute pancreatitis) non-cancer origin (15 patients in each group). The study, of the electrophoretic mobility of red blood cells and clinical analysis of blood was performed at admission of patients to hospital before the start of therapy. Measurement of the electrophoretic mobility of red blood cells produced by microelectrophoresis. The statistical analysis was performed using the software package BIOSTAT and Statistica 6.0 with the use of methods of analysis of variance. It turned out, that benign tumors both of brain tumors and neoplasms of other locations the mobility of red blood cells is higher than in malignant tumors which can be used for their differential diagnosis.