DYNAMICS OF HEMODYNAMIC VARIABLES, SALIVATION, α-AMYLASE ACTIVITY OF DENTAL PATIENTS AS BIOMARKERS OF STRESS REACTIVITY

Dental phobia extraordinary phenomenon in the practice of a dentist, aggravating the actual condition of the patient and complicating diagnostic and treatment interventions. Identifying the predictors of stress and features of stress reactivity of patients determines the possibility of preventive manipulations aimed at reducing the emotional distress of patients. The work attempted to identify, evaluation and certification of biometric indices of stress reactivity of patients suffering from dental pathology. The purpose of the work – to assess the severity of stress reactivity in dental patients on the basis of indicators of arterial pressure, the speed of salivation and the activity of α-amylase. We examined 30 patients, who suffered from dental pathology and underwent treatment at the clinic of prosthetic dentistry of first Moscow state medical University them. I. M. Sechenov, we was examined. Of these, 18 women and 18 men. The patients was divided into three study groups according to age category. Research methods: clinical, physical (laboratory, tonometric, functional), psycho-diagnostic, and statistical. We conducted: identification situational anxiety using State-Trait Anxiety Inventory; the rate of salivation by the method of spitting the mixed saliva; measurement of the rate of saliva secretion was determined by dividing the number of saliva at the time of receiving the secret; measurement of activity of α-amylase by using semi-automatic biochemical analyzer Bio Chem SANTI, spectrophotometric method. The level of reactive anxiety and its correlation with such physiological indicators as blood pressure, the speed of salivation and the activity of α-amylase as markers of stress reactivity in dental patients was assess. The role of identified biomarkers of stress in assessment of the autonomic nervous system as one of the pathophysiological components of mental and emotional stress we investigated. According to the study, treatment dentist made stressful factor for all examined patients. The most vulnerable groups in relation to stress effects, were the subjects of older age groups. Identified the reduction in the rate of salivation after treatment in patients of all groups two times on the background of increasing the activity of α-amylase.