EXPERIMENTAL PHARMACOKINETIC STUDY OF ZINC WHEN ZINC HYDROXIDE NANOFORM IS ADMINISTERED ENTERALY AND INTRAVASCULARY

In vivo experiments on rabbits studied pharmacokinetic properties of Zn2+ under administration of zinc hydroxide nanoparticles (2-3 nm) that were obtained by sol-gel me-thod. Soluble zinc sulfate was selected as a comparison compound. Measurement of plasma Zn2+ levels was carried out by atomic absorption spectrometry with preliminary sample preparation method by wet ashing. Pharmacokinetic parameters were calculated after sin-gle enteral administration (doses – 10, 50 and 100 mg/kg) and single intravenous injection (doses – 10, 50 and 100 mg/kg). Absolute bioavailability for nanoparticles was found to have high values – 33,01±3,55%, 45,15±3,68% and 43,18±2,71% for 10, 50 and 100 mg/kg enteral administration respectively.