THE ROLE OF GENE-GENE INTERACTIONS IN THE FORMATION OF THE GENITAL ENDOMETRIOSIS

The article highlights the bioinformatics analysis data of seven polymorphous loci among 395 patients with genital endometriosis and 981 women from the control group. It was found that the increased risk of genital endometriosis in women of Russia Central region is connected with the combination of alleles C rs2252673 with T rs12444979 with G rs6732220 with G rs7538038 (OR=4.81), and the protective effect have the combination of the following molecular genetic markers: A rs2013573 with T rs2288696 with A rs10980926 (OR = 0.41). Keywords: genital endometriosis, polymorphism, genetic variations, bioinformatics.