STUDY OF ANTI-OSTEOPOROTIC ACTION OF DRUGS FROM THE GROUP OF STATINS
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 10)Publication Date: 2017-10-06
Authors : Oleg S. Gudyrev Alexander V. Faitelson Mikhail V. Pokrovskii Tatyana G. Pokrovskaya Mikhail V. Korokin Alexander P. Grigorenko Olga A. Efremova;
Page : 3780-3785
Keywords : osteoporosis; endothelial dysfunction; statins; atorvastatin; simvastatin; rosuvastatin; strontium ranelate.;
Abstract
In an experiment on female Wistar white rats, the osteoprotective effect of atorvastatin, simvastatin and rosuvastatin was studied in a model of experimental osteoporosis caused by bilateral ovariectomy. It was found that after ovariectomy in female rats develops endothelial dysfunction, including the vessels of the microcirculatory of the bone, leading to a deterioration of blood supply to bone tissue and the occurrence of osteoporosis. It was found that atorvastatin, simvastatin and rosuvastatin, possessing endothelioprotective activity, prevent deterioration of blood supply to bone tissue and thinning of bone trabeculae, thus having anti-osteoporotic activity. Key words: osteoporosis, endothelial dysfunction, statins, atorvastatin, simvastatin, rosuvastatin, strontium ranelate.
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