Effect of Chronic Periodontitis on Serum Lipid Profile: A Randomized, Case Control Clinico-biochemical Study

Background: The localized inflammatory reaction to periodontal pathogenic bacteria or bacterial products is characterized by penetration of the periodontal tissues by inflammatory cells. Recent studies demonstrate the relation between periodontal disease (PD) and hyperlipidemia, which influence the likelihood of PD as an underlying factor for hyperlipidemia. Aim: The aim of this Randomized, case-control type of study was to elucidate the association between serum lipid parameters in periodontally diseased patients with healthy individuals. Material and methods: A total number of 44 subjects were segregated into two groups Group A (Control) Group B (Test). Periodontal parameters including Oral hygiene Index-Simplified (OHI-S), Gingival Index (GI), Probing Depth (PD) and Clinical Attachment Level (CAL) were recorded. Lipid profile comprising of Serum cholesterol, Triglycerides, HDL- Cholesterol and LDL was assessed and co related with periodontal parameters. Results: The results of the present study demonstrated a positive correlation between GI, PD, OHI-S and CAL with serum cholesterol, TG and LDL. The Serum cholesterol, Triglycerides and LDL levels between both the groups showed statistical significance. But the serum HDL levels when compared between both the groups were not statistically significant. Conclusion: The present study showed a definitive positive correlation between PD and increased lipid levels.