Clinical and molecular interrelations of dislipidemia and metabolic phenotype of osteoarthritis
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.25, No. 3)Publication Date: 2017-09-30
Authors : Kabalyk M.A. Sunyaykin A.B.;
Page : 391-398
Keywords : osteoarthritis; osteoarthritis; metabolic phenotype; inflammation; dyslipidemia; atherosclerosis.;
Abstract
The work purpose: analysis of lipid parameters and inflammation markers in metabolic phenotype (MPh) osteoarthritis (OA) in correlation with the clinical manifestations of the disease. The study involved 90 patients with OA of the knee (average age of 64.66±8.43 year), of which 37 patients were with Diabetes mellitus type 2 (group MPh OA). 25 comparable volunteers were a control group. Lipid levels, interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), vasculo-endothelial growth factor A (VEGF-A), atherosclerotic changes of the common carotid artery by ultrasound were determined for all patients. It is shown that when MPh OA patients have a higher atherogenic index (as compared with the control group and patients with OA without the MPh), a greater thickness of the intima-media complex of the common carotid artery and the imbalance of cytokines in favor of increased pro-inflammatory molecules. In MPh OA group there was correlation of atherogenic lipids with proinflammatory cytokines (IL-1β, TNF-α), a marker of endothelial damage (VEGF-A) and clinical manifestations of OA. Thus, the results of the analysis confirm the important role of dyslipidemia and atherosclerosis in the pathogenesis of MPh OA, in particular indicate the possibility of integrating factors of cardiovascular comorbidity via molecular patterns IL-1β, TNF-α, VEGF-A.
Other Latest Articles
- Polymorphism of nitric oxide synthase genes (NOS1 84G/A AND NOS3 786C/T) in patients with bronchial asthma and essential hypertension
- Emel'janov Nikolaj Fedorovich: by the 125-anniversary
- Typology of the human organism system adaptation
- Diagnostic value of microvessel structure in brain glial tumors
- A analysis of various Factor Affecting Transporting Solid and Liquid Suspension through Pipelines
Last modified: 2017-11-02 03:40:55