Hepatoprotective Activity of the Methanolic Extract of the Bark of Khaya senegalensis in Rats against Carbon Tetrachloride (CCl4) -Induced Hepatotoxicity in Adose of (800mg/kg I.P)

This study was carried out to investigate the hepatoprotective effect of the methanolic extract of the bark of sudanese plant Khaya senegalensis, which used in folk medicine for treatment of jaundice. The hepatoprotective effect was tested in rats against carbon tetrachloride (CCl4) -induced hepatotoxicity. Method: Hepatoprotective extracts was given intraperitoneally one hour before injection of CCl4 (800mg/kg I.P) and compared with silymarin, a standard hepatoprotective agent. Result : Methanolic extract of the bark of Khaya senegalensis showed a hepatoprotective effects against CCl4- induced hepatotoxicity, which was evidenced by the significant decrease in ALT, AST and ALP. The methanolic extract of the bark of Khaya senegalensis possessed strong hepatoprotective effect, so we selected it for further biological activity -directed fractionation study. Conclusion: On the light of the present study it is concluded that the methanolic extract of the bark of Khaya senegalensis could protect liver against oxidative damages and could be used as an effective protector against CCl4-induced hepatic damages