Dynamics of Inflammation Markers in the Oral Fluid of Patients with Chronic Herpetic Infection after Dental Implantation in Remote Observation Periods

The article analyses the dynamics of biochemical and immunological inflammation markers in the oral fluid of patients with chronic herpetic infection 6 and 12 months after dental implantation. In the examination of patients in the oral fluid prior to implantation, the content of glycoproteins, sialic acids, IL-1, IL-4 and IL-6 was determined 6 and 12 months after it. In the first group of patients (n=35), the content of glycoproteins in the oral fluid after dental implantation was increased in comparison with the control group by 36.4 %, sialic acids by 47.0 %, IL-1 and IL-6 in 2.6 times and by 35.5 %, respectively. Six months after implantation, glycoprotein content decreased by 28.0%, sialic acids by 22.8 %, IL-1 by 50.9 %, and IL-6 by 23.5 % compared to pre-implantation. After 12 months, the content of glycoproteins in the oral fluid decreased by 26.3 %, sialic acids by 21.3 %, IL-1 by 58.8 %, IL-6 by 29.6 % compared to pre-implantation. In the second group of patients (n=35) the content of glycoproteins in the oral fluid was increased by 40.9 %, sialic acids by 49.3 %, IL-1 by 2.6 times, IL-6 by 39.3 % in comparison with the parameters of the control group. After 6 months, the content of glycoproteins was reduced by 30.0 %, sialic acids by 37.5 %, IL-1 by 60.7 %, IL-6 by 28.4 % compared to pre-implantation. After 12 months, the content of glycoproteins in the oral fluid decreased by 26.8 %, sialic acids by 35.5 %, IL-1 by 59.6 %, and IL-6 by 31.2 % compared to pre-implantation. In both groups of patients, the content of IL-4 did not change at 6 and 12 months after implantation. At 6 and 12 months after implantation, laboratory values in the oral fluid did not differ from the control group. However, it should be noted, that in the second group of patients, where the treatment and prophylactic complex was applied, the content of sialic acids at 6 and 12 months was lower than in the first group at the same time. The content in the oral fluid of IL-1 in the second group of patients was 12 months lower than in the first group. When patients were treated with a therapeutic and prophylactic complex based on antioxidants with anti-inflammatory properties, 6 months after dental implantation, the level of sialic acids in the oral fluid was lower by 17.8 %, IL-1 by 19.2 %, after 12 months – by 16.7 % in comparison with similar indicators in the first group, where the treatment-and-prophylactic complex was not used. At 6 and 12 months after dental implantation, the stabilization of the oral cavity homeostasis was noted in patients of both groups, which indicates the absence of metabolic disturbances in the oral cavity of patients with chronic herpetic infection at distant observation periods after dental implantation.