Synthesis and Anti-bacterial Application of Copper(II) Salicyldehyde Schiff Base Complex

The coordination complex of Cu(II) with the Schiff base derived from salicyldehyde with 5-chloro aniline have been synthesized and characterized by micro analytical data; FT-IR, UV-vis, FAB-mass and X-ray diffraction. Furthermore, in an attempt to improve the antibacterial activity, synthetic analogues i.e. Copper complex has been designed based on the structural properties. Well diffusion method using Nutrient Agar as the medium, we determined the anti-bacterial activity and mechanism of action of these complexes. For antibacterial screening Gram-positive bacteria; Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria; Escherichia coli, Pseudomonas aeruginosa have been used. The synthesized Cu(II) Schiff base ligands show good or moderates antibacterial activity.