FORMULATION DEVELOPMENT AND EVALUATION OF HYDROTROPIC SOLUBILIZATION BASED SUSPENSIONS OF ITRACONAZOLE

Hydrotropic solublization is new, simple, economic, safe method, can be used in analysis of drug. The use of various hydrotropes in place of organic solvents for the purpose of solubilization. Hydrotropes increases the solubility of organics in water. Objective of present investigation was to enhance the solubility of Itraconazole using the technique of hydrotropic solubilization technique and convert them into suitable oral liquid dosage form (suspension) useful for enhancement of bioavailability.0.5M, 1M, 2M of the hydrotropes (trisodium citrate, urea, sodium acetate, sodium benzoate and sodium salicylates) were used to study the saturation solubility. Solubility was found to be greater with trisodium citrate. Suspensions were prepared by using trisodium citrate solution, Itraconazole, xanthan gum, acacia, sodium alginate as a aqueous phase, dispersed phase and suspending agents respectively. Prepared suspensions were characterized for appearance of phases, particle size of dispersed Phase, pourability, sedimentation volume and in vitro drug release. All formulations of tri sodium citrate suspension were uniformly distributed, particle size of the dispersed phase was 10μm to 20μm, suspensions were easily pourable from the bottle and sedimentation volume in the rage of 0.5-1. More than 70% drug release was obtained at the end of the 45 minutes. Hydrotropic solubilization technique for preparation of suspensions of poor water soluble drugs will gave stability to the formulation and helps in enhancement of bioavailability of Itraconazole. Keywords: hydrotropes, solubility, solubilization, Itraconazole, suspensions, bioavailability