ANTICANCER ACTIVITY OF METHANOL EXTRACT OF SESUVIUM PORTULACASTRUM L. WHOLE PLANT AGAINST EHRLICH ASCITES CARCINOMA (EAC)

Aim: To study aims to evaluate the antitumor activity of methanol extract of Sesuvium portulacastrum whole plant (Family: Aizoaceae) on EAC model in Swiss Albino mice. Methods: Evaluation of the antitumor effect of methanol extract of whole plant of Sesuvium portulacastrum on tumor growth and hosts survival time was made by the study of the following parameters: tumor volume, viable and non viable cell count and life span of host. Results: The results showed decrease in tumor volume and cell viability. Hematological studies revealed that, the Hb count decreased in EAC treated mice, whereas, it was induced by the drug treated animals and showed an increase in Hb near to normal levels. Conclusion: The results suggested that, the extracts of whole plant of Sesuvium portulacastrum exhibited significant antitumor activity on EAC bearing mice. Keywords: Sesuvium portulacastrum, antitumor, lifespan, WBC.