Inflammatory Biomarkers and Endothelial Dysfunction among Obese Patients with Type 2 Diabetes: A Correlational Study

Background: Systemic inflammation and endothelial dysfunction induce vascular complications of diabetes mellitus that impose a huge burden on diabetes mellitus complications management. Objective: The aim of the present study was to investigate the possible relationship between systemic inflammation and endothelial dysfunction in obese patients with type 2 diabetes. Materials and Methods: Forty obese patients with type 2 diabetes (24 males and 16 females) with body mass index (BMI) ranged from 31 to 35 Kg/ m2, non smokers, free from respiratory, kidney; liver, metabolic and neurological disorders participated in this randomized controlled trial. Their age ranged from 40 to 55 years were randomly included in this study as the first group (A). While a forty non-diabetic subjects (23 males and 17 females) not suffering of any disease, their age ranged from 40 to 52 years were included in this study as the second group (B) and considered as a control group. Results: Diabetic patients showed significantly higher values of TNF-α, IL-6, CRP, HBA1c, ICAM-1, VCAM-1 and E-selectin in comparison to controls. Also, there was significant positive correlation between inflammatory and endothelial dysfunction biomarkers among obese diabetic patients. Conclusion: There was a strong association between elevated biomarkers of systemic inflammation and endothelial dysfunction among obese patients with type 2 diabetes.