Content Dihydrotestosterone Levels in Postmenopausal Women According to the Comorbid Disease: Type 2 Diabetes and Hypertension

Introduction. Postmenopausal women ­ one of the most critical periods in which modern woman spends a third of her life, and therefore the study of this problem is of particular interest. Today is proved the activity of steroidogenic ovarian function in postmenopausal women. It is known that one of the most biologically active forms of testosterone in men and women, which is formed from testosterone directly into the cells “respective authorities target” is dihydrotestosterone (DHT). It is also reported that testosterone may be involved in metabolic disorders glucose in healthy women and about the relationship between high levels of free testosterone incidence of type 2 diabetes mellitus (DM). The presence of the relative hyperandrogenemia may be related to the risk of cardiovascular diseases in postmenopausal women. However, despite the numerous studies of the peculiarities of androgens in the female body, until now this issue has not received its final decision. The aim of the study was to find out the features of the contents of DHT levels in postmenopausal women according to the comorbid diseases DM type 2 and hypertension (HT). Materials and methods. The study involved 137 females aged 45­60 years. Patients were stratified into three groups: 30 patients with type 2 DM (1st group), 34 patients with HT (2nd group), 42 patients with type 2 DM and HT (3rd group). Control of group ­ 31 postmenopausal women without the disease. In blood serum using ELISA methods were tested folitropin, DHT and concentration glucose and glycosylated hemoglobin (НbА1с). Results and discussion. Found that in patients with HT in postmenopausal was observed a statistically significant increase in the concentration preprandial glycemia and content НbА1с, DHT levels compared to women with postmenopausal without the disease. Joining hypertension in patients with type 2 DM accompanied by more pronounced, statistically significant increase of preprandial glycemia and НbА1с and most statistically significant DHT. Among indicators of glucose concentration, НbА1с DHT levels and there is a direct correlation, indicating a direct positive indicators of glucose dependence concentration in blood and the content НbА1с, DHT. Conclusions. In patients with HT in postmenopausal was observed a statistically significant increase in DHT concentrations in the blood compared to women with postmenopausal without the disease. At the same time in patients with type 2 DM, compared to patients with HT verified a clear increase in the content of DHT in the blood. Thus, to forecast the possibility of type 2 DM and comorbid HT during examination in postmenopausal women, should be considered the level of serum DHT.