EFFECT OF ALCOHOLIC EXTRACT OF Brassica oleracea L. VAR. CAPITATA PLANT LEAVES ON GLUCOSE LEVEL AND ANTIOXIDANT ACTIVITY IN ALLOXAN-INDUCED DIABETIC RATS

Objective: The aim of this study was to investigate the effect of ethanolic extract of Brassica oleracea var. Capitata (Cabbage) Plant Leaves of Glucose Level and Antioxidant Activity in Alloxan-Induced Diabetic Rats. Methods: Thirty mature male rats were used in five groups, the first group kept as a normal group. The second group (Diabetic group) received a single dose of alloxan (150 mg/kg BW i.p.) to induction of Diabetes mellitus type 2 (T2DM) while the third, fourth, and fifth groups were diabetic rats received 150, 300, 600 mg/kg, respectively, of Brassica oleracea var. capitata ethanolic extracts orally for 60 days after induction of T2DM. Body weights were recorded after and before treatment. Animals were sacrified after 24 h of the last dose and heart blood samples were collected for biochemical study. Results: The presence of a significant decrease (P < 0.05) in the body weights and reduced Glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase1 (GPX1) levels and significant increase (P < 0.05) in the Fasting plasma Glucose (FPG) and malondialdehyde (MDA) levels in the diabetic group compared with normal group. In contrast, it was noted the presence of significant increase (P < 0.05) in the body weights and GSH, SOD and GPX1 levels and significant decrease (P < 0.05) in the FPG and MDA levels in diabetic rats that treated with 300, 600 mg/kg BW of extract as compared with diabetic group rats. Conclusion: The present study ascertains that the Ethanolic extracts of Brassica oleracea var. Capitata Plant Leaves possesses antihyperglycemic and antioxidant properties.