Proteomics as a Tool to Decipher Novel Mechanistic Candidates in Cardiac Pathophysiology

Cardiovascular diseases resulting in heart failure remain one of the leading causes of mortality the world over. They were accountable for 31% of global deaths in 2012[1]. In view of this, a huge amount of research has been targeted towards diagnoses, prevention and therapeutic intervention of cardiovascular disease forms with a mind to abate the incidence of heart failure. While experimental research has given the bulk of breakthroughs, management procedures and understanding of cardiovascular diseases, a systems biology approach is enhancing and reshaping the way research is carried out and data is interpreted in this field. It is yielding such beneficial results of itself and in conjunction to experimental biology that would not be possible for the latter alone. The purpose of this review is to succinctly catalogue two relevant systems biology approaches being used currently in cardiac biology and highlighting the important contributions made by them.