Faulty Perinatal Hormonal Imprinting Caused by Exogeneous Vitamin D – Dangers and Problems

Hormonal imprinting takes place perinatally at the first encounter between the developing hormone receptor and its target hormone. The imprinting is absolutely needed and determines the binding capacity of the receptor for life. However, when the developmental window for imprinting is open, related molecules (other hormones of the hormone family, synthetic hormones, certain drugs, environmental pollutants [endocrine disruptors] etc) can bind to the receptor and faulty imprinting develops, which also has a life-long effect. The faulty hormonal imprinting is a functional teratogen. The transformed, active form of vitamin D (calcitriol) is a steroid hormone, the receptor of which belongs to the steroid receptor superfamily. Consequently, a single vitamin D treatment can execute faulty imprinting in the related receptors of the family. This causes life-long alterations in the hormone receptor's binding capacity, hormone synthesis of immune cells, ossification, brain neurotransmitter level, myocardial ouabain binding and sexual behavior, causing or helping the initiation of different diseases in adult age. The effect of hormonal imprinting is epigenetic and manifested also transgenerationally. The paper call attention that not only the problems caused by vitamin D deficiency could be considered, but the imprinting effect of the hormone excess. The change of vitamin-D name to hormone-D or, considering its many effects, multihormone-D is proposed, which could influence the mentality of the laity and doctors. In addition the thorough observation of human late effects is recommended.