THE STATE OF NEUROMEDIA IN RAT BRAIN STRUCTURES CAUSED BY CHRONIC AND INTERRUPTED ALCOHOL INTOXICATION

Background. The results of the literature review show that functional state violations of the brain neurotransmitter systems play a key role in the formation of alcohol intoxication signs and the development of addiction syndrome. Purpose of study. To study the influence of chronic (ChAI) and interrupted (IAI) alcohol intoxication with different intervals of ethanol administration on the state of neurotransmitter systems and the level of neurotransmitter amino acids in brain structure of rats. Material and methods. 30 white outbred rats weighing 180-220 g. The content of free amino acids and biogenic amines was determined by HPLC. Results. IAI was not accompanied by changes in the neurotransmitters concentrations in the cortex and the cerebellum. In the striatum IAI-1caused the increase in tyrosine and tryptophan concentration, whereas IAI-4 increased the content of noradrenalin. Conclusions. СhAI and PAI are characterized by the development of neurotransmitter disorders in the studied regions of the brain, with the development of the most pronounced shifts in the striatum.