Acellular Matrix of Swim Bladder for the Reconstruction of Abdominal Wall Defects in Rabbit - An Immunological Study

The abdominal wall reconstruction with fresh swim bladder, acellular swim bladder and autografts after creating an abdominal wall defect of 3 x 4 cm was performed in rabbits. Analysis of exudate collected from surgical wound, the fresh graft group showed variable levels of interleukins where as autograft and processed graft groups showed no appreciable levels of interleukins. The concentration of Transforming growth factor  2 was high in fresh graft group followed by processed and autografts indicates a high requirement of TGF for tissue repair in fresh grafts when compared to the decellularized ones.