SYNTHESIS, SPECTRAL AND BIOLOGICAL STUDIES OF MIXED LIGAND TRANSITION METAL COMPLEXES OF NITROKETENE DITHIOACETAL WITH EPHEDRINE

Metal ions play an important role in bioinorganic chemistry. Metals such as iron, cobalt, nickel, copper and zinc may exist in trace amounts in biological systems. Also, metal has played an important role in medicine for years; Metal ions play a vital role in a vast number of widely differing biological processes. They have a considerable effect in biological processes and depending on their concentration; they may either contribute towards the health of the organism or cause toxicity [35]. Also, metal has played an important role in medicine for years; many are essential in human diet in varying amounts and some are used in the medical profession as invaluable diagnostic tools. Metal ions play a vital role in a vast number of widely differing biological processes. They have a considerable effect in biological processes and depending on their concentration; they may either contribute towards the health of the organism or cause toxicity [1]. Ephedrine is a synthetic sympathomimetic amine [8,9] acts on part of the sympathetic nervous system (SNS). In synthetic organic chemistry, the nitroketene dithioacetal motif (NKDA) based organo sulfur compounds are well known intermediates as a two carbon push–pull system.[10,11] The nitro group acts as a powerful electron-withdrawing group and the two alkylated sulfur atoms readily donate their lone-pair of electrons to make the entire NKDA motif frame work as highly polarized system.(1-7) Thorough literature search in the field of nitroketene dithioacetal chemistry showed that there is no report that NKDA has been used as inorganic ligand. It made a new route of synthesizing transition metal complexes with Nitroketene dithioacetal as one ligand which is an organic moiety. The synthesized mixed ligand transition metal complex with drug like ephedrine is also a new novel route in inorganic chemistry. The drug activity can be improved by changing it into new complexes. The biological activity of the drug molecules were compared with the synthesized metal complexes and found that the complexes show better antibacterial activities than the drug ephedrine. Also Central nervous system studies were carried out with synthesized complexes and found that the complexes have CNS depressant activities.(12,13) Hence as a future work the complexes those were synthesized can be used as CNS depressant drugs. The structure of the synthesised complex were characterised using UV, IR, 1H, 13C NMR spectral, EDX analysis, C,H,N elemental analysis and fabmass spectral analysis. Key words: Metal-drug complexes, Ephedrine, Nitroketene dithioacetal, antibacterial studies, Central nervous system activity.