BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT

A series of phenylmethylenehydantoin and phenylmethylenerhodanine derivatives (Der 1 to Der 8) were synthesized. These newly synthesized derivatives have been characterized by elemental analysis molecular weight measurements as well as spectral (IR, 1H NMR 13CNMR) studies. All the compounds show significant increase in liver glycogen level at 25 mg/kg dose levels, in- vivo & these compounds were also screened for anti diabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity at 25 mg/kg dose levels.