THE HPTLC QUANTITATION OF VITEXIN IN OXALIS CORNICULATA LEAVES AND SCREENING OF ITS NEPHROPROTECTIVE ACTIVITY
Journal: Indian Drugs (Vol.49, No. 3)Publication Date: 2012-03-28
Authors : Divakar M. C. Lakshmidevi S.; Sreenivasan N.;
Page : 30-39
Keywords : ;
Abstract
In the present work an attempt has been made to analyze quantitatively the content of vitexin in Oxalis corniculata leaves and its protective activity on gentamicin and cisplatin induced nephrotic damage in albino rats. Vitexin is 8-beta-D glucopyranosyl apigenin found commonly in Oxalis corniculata, a plant of good repute in Ayurvedic system of medicine. The HPTLC analysis data indicated that the collected Oxalis corniculata leaves contain 289.8 mg/g of vitexin. The leaf methanolic extract of O. corniculata (OCLM) as well as vitexin showed significant protection on gentamicin and cisplatin induced nephrotoxicity in albino rats. Both OCLM and vitexin produced significant scavenging effect upon hydroxyl, lipid peroxide and superoxide, free radicals. OCLM showed better diuretic effect as compared to vitexin.
Other Latest Articles
- SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW BENZIMIDAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS
- VEGETATION MONITORING:SOME METHODOLOGICAL AND METHODIC ASPECTS OF MONITORING WHILE PLANNING TECHNICAL BUILDING
- SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HETEROCYCLES CONTAINING OXADIAZOLE AND PYRAZOLE RING FOR ANTI-BACTERIAL, ANTI-FUNGAL AND ANTI-TUBERCULAR ACTIVITIES
- COLON TARGETING APPROACHES: PAST, PRESENT AND FUTURE
- A SIMPLE METHOD FOR ISOLATION OF MARMELOSIN (IMPERATORIN) FROM FRUITS OF AEGLE MARMELOS CORREA
Last modified: 2018-03-01 14:41:34