NOVEL 4-OXO-[1, 3-THIAZOLIDINE-3-YL] BENZAMIDE AND ITS DERIVATIVES AS POTENT ANTIPROTOZOAL FERREDOXIN MARKER INTERACTION WITH LIGANDS: DISCOVERY OF NEW DRUG

In this paper, we synthesized the compound N-[2-(4-methoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4- carboximide(IV) were synthesized. . The chosen ligands have conformational stability and structural diversity in relation to the bound ligands of the N-[2-(4-methoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboximide (IV) crystal structure. The ligand structures used in docking were obtained from Pubchem compound database. Ligands were identified as per the pharmacokinetic parameter and solubility. The active site i.e. ferredoxin enzyme in the protein interacts with ligands of the substrate and gives rise to the catalytic activity to test ligands that helps in determining the binding pattern of the ligands to the active site of ferredoxin enzyme. The pharmacological study was undertaken to evaluate the effects of substituents on the antiprotozoal activity. The synthesized compounds exhibited better antiprotozoal activity towards Paramecium caudatum, Vorticella campanula, it can be inferred that as the OCH3, SH, NH group substitution on the ring causes an increase in the intensity of the activity against Paramecium caudatum, Vorticella campanula , Opalina ranarum and have potent antiprotozoal activity. Key words: Thiazolidinones, molecular docking and antiprotozoal activity.