ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE LOVASTATIN DRUG BY SOLID DISPERSION METHOD

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, solubility increases hence bioavailability may be significantly improved. They are usually presented as amorphous products, mainly obtained by two major different methods, melting and solvent evaporation KeyWords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG), degree of porosity, Renex, Texafor AIP