FORMULATION AND IN VITRO EVALUATION OF FESOTERODINE FUMARATE SUSTAINED RELEASE TABLETS

The aim of the present study was to develop Sustained release formulation of Fesoterodine Fumarate to maintain constant therapeutic levels of the drug for over 12 hrs. Here different types of polymers (Locust Bean Gum, Gum Cyamposis, Corn Sugar Gum) were used. Fesoterodine Fumarate dose was fixed as 8 mg. Total weight of the tablet was considered as 100 mg. Polymers were used in the concentration of 10, 20 and 30 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that Among all formulations F2 formulation was considered as optimised formulation. It was shown 99.65% drug release at 12hrs. The optimised formulation F2 was followed Higuchi release kinetics. Keywords: Fesoterodine Fumarate, Locust Bean Gum, Gum Cyamposis, Corn Sugar Gum, Sustained release tablets, Natural Polymers.