New Spectrophotometric Estimation of Cefixime in the Tablets Using Mixed Solvency Approach

Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Cefixime by use of mixed solvency concept. Cefixime shows maximum absorbance in the concentration range of 5-25 µg/ml at 288 nm. Method of analysis has been validated for different parameters like linearity, accuracy, precision, LOD and LOQ. The percent drug estimated in tablet formulation of Batch-I and of Batch-II were 98.60±0.372 and 99.12±0.764 respectively. The range of percent recoveries varied from 97.46±0.400 to 99.65±0.481. Sodium caprylate, 10% Sodium caprylate, 10% Sodium citrate and 10% urea blend do not interfere. The analytical method was found to be simple, safe (free from toxicity), economic and eco-friendly.