THE LIVER FUNCTIONAL STATE CHANGES IN PATIENTS WITH UROGENITAL CHLAMYDIOSIS IN THE PROCESS OF TREATMENT

Chlamydial infection affects organs of urinary, respiratory, reproductive, nervous, cardiovascular systems, causes diseases of the eyes, joints, and liver. The liver in many cases influences the course of the disease and the effectiveness of the treatment. The purpose of the research is to study changes in the liver function in patients with urogenital chlamydial infection under the influence of basic treatment. 65 patients with urogenital chlamydial infection were examined. Liver function was evaluated through ultrasound and biochemical findings with sets of firms ‘Lahem' and ‘Fenice' used for that purpose. Basic treatment of patients with chlamydial infection included antibiotic of macrolide group - Josamycin, and Fluconazole to prevent candidiasis. According to the results of the study, 29 patients (44.62%) with chlamydial infection showed liver function abnormalities at the study baseline: cytolysis syndrome in 38.46% of cases, cholestasis syndrome in 6.75% of cases, reducing of the synthesis liver function in 13.85% of cases, exertion of energy processes in the liver in 32.30% of cases, exertion of oxidoreduction processes in 41.53% of cases. Basic therapy conducted to the patients with chlamydial infection contributed the clinical and bacteriological cure. After the treatment 44 patients (67.69%) had the liver function abnormalities: in 18.46% of cases there was heaviness in the right upper area; developing of cytolysis syndrome was observed in 49.23% of cases, cholestasis syndrome in 18.46% of cases, and reduces the synthesis function of the liver in 27.70% of cases, exertion of the energy processes in the liver in 47.69% of cases, exertion of oxidoreduction processes in 63.07% of cases (p <0.05). After a basic course of chlamydial infection treatment with the use of macrolide antibiotic and fluconazole, there was increase of frequency and severity of major liver abnormalities. Obtained results show that it is necessary to modify existing guidelines for Chlamydia trachomatis infection diagnostics and treatment to take possible abnormalities of liver function into account.