SIMULTANEOUS ESTIMATION OF TELMISARTAN, CHLORTHALIDONE AND CILNIDIPINE BY ABSORBANCE CORRECTION METHOD USING UV SPECTROPHOTOMETRY

A new, simple, sensitive and accurate UV spectrophotometric absorption correction method has been developed for simultaneous determination of telmisartan, chlorthalidone and cilnidipine in combined tablet dosage form. The wavelengths selected for the analysis were 325 nm, 225 nm and 350 nm for telmisartan, chlorthalidone and cilnidipine respectively. Beer's law obeyed the concentration range of 10 - 80 µg/ ml, 3.12 – 25 µg/ ml and 5 - 40 µg/ ml for telmisartan, chlorthalidone and cilnidipine, respectively. Methanol is used as solvent. The mean percentage recovery was found in the range of 100% to 100.6% for TEL, 98.6% to 101.3% for CHL and 100% to 101.3% for CLD. The developed method was validated statistically. The % RSD value was found to be less than 2. Thus the proposed method was simple, precise, economic, rapid, accurate and can be successfully applied for simultaneous determination of telmisartan, chlorthalidone and cilnidipine in combined tablet dosage form. Keywords: Telmisartan, Chlorthalidone, cilnidipine.