An Improved and Scalable Method Developed for the Synthesis of 2-[4-[(4-Chlorophenyl) Phenyl Methyl]-1-Piperazinyl] Ethanol, A Key Intermediate for Cetirizine which is Antiallergic Drug
Journal: International Journal of Chemical & Petrochemical Technology (IJCPT) (Vol.4, No. 2)Publication Date: 2014-04-30
Authors : Nitin Pawar; Sanjay B. Patil; Ravindra D. Patil;
Page : 1-4
Keywords : 2-[4-[(4-Chlorophenyl) Phenyl Methyl]-1-Piperazinyl] Ethanol; Sodium Iodide; Solvent Free Reaction; Antiallergic Drug Cetirizine;
Abstract
An improved and scalable method developed for the synthesis of 2-[4-[(4-chlorophenyl) phenyl methyl]-1-piperazinyl] ethanol, a key intermediate for Cetirizine which is antiallergic drug, Starting from commercially available 4-Chlorobenzhydryl piperazine and 2- Chloro ethanol in presence of base Di isopropyl Ethyl Amine and sodium Iodide as a catalyst the method is easy, inexpensive and reproducible and the process is clean and operationally simple.
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Last modified: 2014-05-01 21:25:27