A REVIEW ON OSMOTIC DRUG DELIVERY SYSTEM IN TREATING HYPERTENSION BY ATENOLOL

Hypertension results from increased peripheral vascular smooth muscle tone which leads to increased arteriolar resistance and reduced capacitance of the venous system. Elevated BP is an extremely common disorder and many of the individuals have no symptoms. Chronic hypertension either systolic or diastolic can lead to congestive heart failure, myocardial infarction, renal damage and cerebro vascular accidents. The beta blockers are used individually or in a combination therapy to treat hypertension. The development of oral osmotic systems has a strong and good market potential. Atenolol is a cardio selective beta-1 blocking agent which is used to reduce systolic and diastolic B.P and it is widely used to treat hypertension, introduced in the year 1976. It reduces heart rate and cardiac output when resting and during exercise. The osmotic drug delivery system utilises the principle of osmosis and drug release is aimed to release by zero order kinetics, to prolong the release of the drug for longer duration of time, providing the treatment in controlled manner by reducing the multiple dosing of drug. Keywords: Atenolol, Beta -1 blocking agent, Diastolic, Hypertension, Systolic, Osmotic, Zero order.